July 2018 UPDATE: If you’re looking to export multiple PDFs, using multiple PDF export presets, into multiple folders, using super-flexible filenaming options (including filenames based on the contents of the page itself), our newly updated Extract Pages script is for you! Click here for all the details.

Back in May (2015), someone asked on the Adobe forum if there was a way to export 2 pdfs from InDesign at once, using different presets.

The answer was the following little script, which can be easily adapted to exported more than just 2 PDFs, using any existing PDF presets you like:

// BS"D 
// All rights reserved (c) 2015 by Id-Extras.com 
// Free to use and modify but do not delete this copyright attribution. 
// This script will export 2 pdfs of the current document 
// Choose the PDF presets by altering their names below 
// The second PDF gets a suffix added to its name. 
// Modify the line below beginning name2 = to change the suffix. 
// For more InDesign scripts: www.Id-Extras.com 
d = app.activeDocument; 
// Here you can choose the PDF preset 
preset1 = app.pdfExportPresets.itemByName("[High Quality Print]"); 
preset2 = app.pdfExportPresets.itemByName("[Smallest File Size]"); 
if (!(preset1.isValid && preset2.isValid)){ 
 alert("One of the presets does not exist. Please check spelling carefully."); 
 exit(); 
} 
if (d.saved){ 
 thePath = String(d.fullName).replace(/\..+$/, "") + ".pdf"; 
 thePath = String(new File(thePath).saveDlg()); 
} 
else{ 
 thePath = String((new File).saveDlg()); 
} 
thePath = thePath.replace(/\.pdf$/, ""); 
name1 = thePath+".pdf"; 
// Here you can set the suffix at the end of the name 
name2 = thePath+"_xx.pdf"; 
d.exportFile(ExportFormat.PDF_TYPE, new File(name1), false, preset1); 
d.exportFile(ExportFormat.PDF_TYPE, new File(name2), false, preset2);

Enjoy!